| Day | Date | | Opponent | Score | | | Location | Venue | Attendance | Notes |
|---|
| Fri | 9/20/1935 | H | Wisconsin Cardinals | 26-0 | W | | St. Louis, MO | Edward Walsh Memorial Stadium | 2700 | |
| Tue | 9/24/1935 | H | Chicago Cardinals | | - | | St. Louis, MO | | | Canceled |
| Thu | 10/3/1935 | A | Louisville Bourbons | 13-0 | W | | Louisville, KY | Parkway Field | 8000 | |
| Wed | 10/9/1935 | H | Louisville Bourbons | 0-7 | L | | St. Louis, MO | Edward Walsh Memorial Stadium | 3212 | |
| Sun | 10/13/1935 | H | Calumet All-Stars | 0-0 | T | | St. Louis, MO | Edward Walsh Memorial Stadium | 1500 | Postponed from 9/26 |
| Sun | 10/20/1935 | A | Louisville Pros | 14-16 | L | | Louisville, KY | Parkway Field | 800 | |
| Sat | 10/26/1935 | N | Louisville Pros | 13-13 | T | | Paducah, KY | | 1300 | |
| Tue | 10/29/1935 | A | Calumet All-Stars | 6-13 | L | | Indiana Harbor, IN | Washington High School Field | 4000 | |
| Sun | 11/3/1935 | H | Canton All-Stars | 33-14 | W | | St. Louis, MO | Public Schools Stadium | 1500 | |
| Sun | 11/17/1935 | H | Memphis Tigers | | - | | St. Louis, MO | | | Canceled |
| Sun | 11/24/1935 | A | Poplar Bluff All-Stars | 13-0 | W | | Poplar Bluff, MO | | 4000 | |
| Sun | 12/1/1935 | A | Memphis Tigers | | - | | Memphis, TN | Hodges Field | | Canceled |
